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Gardner, Matthew and Bowden, Celeste and Manzoor, Shoaib and Cozier, Gyles E and Andrews, Rachael C and Craft, Sam and Skumlien, Martine and Sunderland, Peter and Tooth, Tom and Collins, Peter and Power, Alexander and Haines, Tom SF and Freeman, Tom P and Scott, Jennifer and Sutcliffe, Oliver B and Bowman, Richard W and Husbands, Stephen M and Pudney, Christopher R (2025) Field-portable device for detection of controlled and psychoactive substances from e-cigarettes. ACS Omega , 10 , (8) , pp. 7839-7847.
Curtis, Blake and Lawes, Douglas and Caldicott, David and McLeod, Malcolm D (2024) Identification of the novel synthetic opioid N-pyrrolidino isotonitazene at an Australian drug checking service. ChemRxiv , Early online .
De Vrieze, Liam M and Stove, Christophe P and Vandeputte, Marthe M (2024) Nitazene test strips: a laboratory evaluation. Harm Reduction Journal , 21 .
Barone, Rossella and Pelletti, Guido and Giorgetti, Arianna and Mohamed, Susan and Pascali, Jennifer Paola and Sablone, Sara and Introna, Francesco and Pelotti, Susi (2024) Validation and application of a method for the quantification of 137 drugs of abuse and new psychoactive substances in hair. Journal of Pharmaceutical and Biomedical Analysis , 243 .
Killoran, Sarah and McNamara, Sinéad and Kavanagh, Pierce and O'Brien, John and Lakes, Rodney (2024) Identification of N-pyrrolidino protonitazene in powders sold as heroin and associated with overdose clusters in Dublin and Cork, Ireland. Drug Testing and Analysis , Early online .
Bade, Richard and Nadarajan, Dhayaalini and Driver, Erin M and Halden, Rolf U and Gerber, Cobus and Krotulski, Alex and Hall, Wayne and Mueller, Jochen F (2024) Wastewater-based monitoring of the nitazene analogues: First detection of protonitazene in wastewater. The Science of the Total Environment , 920 .
Taoussi, Omayema and Berardinelli, Diletta and Zaami, Simona and Tavoletta, Francesco and Basile, Giuseppe and Kronstrand, Robert and Auwärter, Volker and Busardò, Francesco P and Carlier, Jeremy (2024) Human metabolism of four synthetic benzimidazole opioids: isotonitazene, metonitazene, etodesnitazene, and metodesnitazene. Archives of Toxicology , 98 , pp. 2101-2116.
De Vrieze, Liam M and Stove, Christophe P and Vandeputte, Marthe M (2024) Nitazene test strips: a laboratory evaluation. Harm Reduction Journal , 21 .
Killeen, Nicki and Lakes, Rodney and Webster, Mairead and Killoran, Sarah and McNamara, Sinéad and Kavanagh, Pierce and Eagleton, Marie and McCormack, Seamus and Micheau, Eva and Moughty, Adrian and O'Donnell, Cathal and O'Reilly, Martin and Doyle, Gavin and O'Rourke, Sean and Downing, Sally and Flynn, Caoimhe and Keenan, Eamon (2024) The emergence of nitazenes on the Irish heroin market and national preparation for possible future outbreaks. Addiction , 119 , (9) , pp. 1657-1658.
Giraudon, Isabelle and Abel-Ollo, Katri and Vanaga-Arāja, Diāna and Heudtlass, Peter and Griffiths, Paul (2024) Nitazenes represent a growing threat to public health in Europe. The Lancet Public health , 9 , (4) , E216.
De Vrieze, Liam M and Walton, Sara E and Pottie, Eline and Papsun, Donna and Logan, Barry K and Krotulski, Alex J and Stove, Christophe P and Vandeputte, Marthe M (2024) In vitro structure-activity relationships and forensic case series of emerging 2-benzylbenzimidazole 'nitazene' opioids. Archives of Toxicology , 98 , pp. 2999-3018.
Holland, Adam and Copeland, Caroline S and Shorter, Gillian W and Connolly, Dean J and Wiseman, Alice and Mooney, John and Fenton, Kevin and Harris, Magdalena (2024) Nitazenes-heralding a second wave for the UK drug-related death crisis? The Lancet Public Health , 9 , (2) , E71-E72.
Holland, Adam and Copeland, Caroline (2023) Responding to nitazenes in the UK drugs market. Transform blog .
Nahar, Limon K and Andrews, Rebecca and Paterson, Sue (2023) Rapid response: Evolving use of recreational drugs in UK – Nitazenes and Xylazine. BMJ , 383 , p. 2280.
Pergolizzi, Joseph and Raffa, Robert and LeQuang, Jo Ann K and Breve, Frank and Varrassi, Giustino (2023) Old drugs and new challenges: a narrative review of nitazenes. Cureus , 15 , (6) .
Di Trana, Annagiulia and Pichini, Simona and Pacifici, Roberta and Giorgetti, Raffaele and Busardò, Francesco Paolo (2022) Synthetic benzimidazole opioids: the emerging health challenge for European drug users. Frontiers in Psychiatry , 13 .
TEDI members. Jones, G and Ventura, Mireia and Rigoni, Rafaela and Schiffer, Katrin (2025) European drug checking trends 2018 - 2024. Amsterdam: Correlation – European Harm Reduction Network.
Health Research Board. Irish National Focal Point to the European Drugs Agency. (2025) Ireland: national report for 2024 - drug markets and crime. Dublin: Health Research Board.
Public Health Scotland. (2025) Rapid Action Drug Alerts and Response (RADAR) quarterly reports 2025. Edinburgh: Public Health Scotland.
United Kingdom. Home Office. (2025) UK circular 002/2025: The Misuse of Drugs Act 1971 Order 2024. Changes to the Misuse of Drugs Act 1971 to control 22 substances, with 2-benzyl benzimidazole variants (nitazenes) falling under a new generic definition. London: Home Office.
Advisory Council on the Misuse of Drugs. (2024) ACMD report – A review of the evidence on the use and harms of 2-benzyl benzimidazole (‘nitazene’) and piperidine benzimidazolone (‘brorphine-like’) opioids. London: Advisory Council on the Misuse of Drugs.
Public Health Scotland. (2024) Rapid Action Drug Alerts and Response (RADAR) quarterly reports 2024. Edinburgh: Public Health Scotland.
United Kingdom. Office for Health Improvement & Disparities. (2024) Deaths linked to potent synthetic opioids [England]. London: Office for Health Improvement & Disparities.
WEDINOS. (2024) PHILTRE August 2024. Cardiff: WEDINOS.
Welsh Government, Public Health Wales, Cardiff University, Cardiff and Vale University Health Board. (2024) WEDINOS: Philtre annual report April 2023 – March 2024. Cardiff: WEDINOS.
Forensic Science Ireland. (2024) Forensic Science Ireland annual report 2023. Dublin: Forensic Science Ireland.
Walton, Sara E and Garrett, Rachel and Denn, Max T and Quinter, Alexis D and DeBord, Joshua and Logan, Barry K and Krotulski, Alex J (2024) Methylenedioxynitazene — NPS Discovery new drug monograph. United States: Center for Forensic Science Research and Education.
Walton, Sara E and Roberts, Dakota and Altomare-Jarczyk, Cole and Edelmann, Abby and Davis, Jamie and Dennehy, Mary and Quinter, Alexis D and DeBord, Joshua and Green, Traci C and Logan, Barry K and Krotulski, Alex J (2024) 5-Methyl Etodesnitazene — NPS Discovery new drug monograph. United States: Center for Forensic Science Research and Education.
The State Laboratory. (2024) The State Laboratory annual report 2023. Dublin: The State Laboratory.
Care Quality Commission. (2024) The safer management of controlled drugs: annual update 2023. London: Care Quality Commission.
United Nations Office on Drugs and Crime. (2024) The challenge of new psychoactive substances - a technical update. Vienna: United Nations.
Public Health Scotland. (2024) Rapid Action Drug Alerts and Response (RADAR) quarterly report: April 2024 (correction 4 June 2024). Edinburgh: Public Health Scotland.
Man, Nicola and Sadaphale, Vandit and Barratt, Monica J and Bruno, Raimondo and Sutherland, Rachel and Peacock, Amy (2024) Availability of nitazenes for purchase in Australia and internationally via cryptomarkets. Sydney: National Drug and Alcohol Research Centre.
United Kingdom. Home Office. (2024) 001/2024: The Misuse of Drugs Act 1971 (Amendment) Order 2024 and The Misuse of Drugs and Misuse of Drugs (Designation) (England and Wales and Scotland) (Amendment and Revocation) Regulations 2024. London: Home Office.
HSE National Clinical Lead for Addiction Services, National Red Alert Group. (2024) Synthetic opioid preparedness. Fact sheet for medical care providers. Dublin: HSE drugs.ie.
Pardal, Mafalda and Wadsworth, Elle and Kilmer, Beau (2024) Illegal synthetic opioids. Can Europe prevent a crisis? CA: RAND Corporation.
Krotulski, Alex J and Becker, Katie and Walton, Sara E and Papsun, Donna M and Fogarty, Melissa F and Logan, Barry K (2023) N-Desethyl Etonitazene – NPS Discovery new drug monograph. United States: Center for Forensic Science Research and Education.
WEDINOS. (2023) PHILTRE annual report April 2022 - March 2023. Cardiff: WEDINOS.
Krotulski, Alex J and Shinefield, Jennifer and Teixeira da Silva, Daniel and Mohr, Amanda L A and DeBord, Joshua and Walton, Sara E and Logan, Barry K (2023) New potent synthetic opioid— N-Desethyl Isotonitazene —proliferating among recreational drug supply in USA. United States: Center for Forensic Science Research and Education.
Krotulski, Alex J and Newman, Reta and Gilbert, Michael and Walton, Sara E and Fogarty, Melissa F and Logan, Barry K (2022) N-Desethyl Isotonitazene. United States: Center for Forensic Science Research and Education.
NPS Discovery. (2022) NPS discovery toolkit: N-Pyrrolidino Etonitazene. United States: Center for Forensic Science Research and Education.
Ontario Agency for Health Protection and Promotion (Public Health Ontario). (2022) Novel non-fentanyl synthetic opioids: risk assessment and implications for practice. Toronto: Queen's Printer for Ontario.
Oja, Mikk and Kurbatova, Aljona and Abel-Ollo, Katri (2021) Key lessons from Estonia. The Netherlands: SO-PREP.
European Monitoring Centre for Drugs and Drug Addiction. (2020) Risk assessment report on the new psychoactive substance N,N-diethyl-2-[[4-(1-methylethoxy)phenyl]methyl]-5-nitro-1H-benzimidazole-1- ethanamine (isotonitazene) in accordance with Article 5c of Regulation (EC) No 1920/2006. Luxembourg: Publications Office of the European Union.
European Union Drugs Agency. (2024) New psychoactive substances – the current situation in Europe (European Drug Report 2024). URL: https://www.euda.europa.eu/publications/european-d...
European Union Drugs Agency. (2024) Drug-induced deaths – the current situation in Europe (European Drug Report 2024). URL: https://www.euda.europa.eu/publications/european-d...
(2024) Synthetic opioid preparation. HSE update on the emergence of synthetic opioids on the Irish heroin market. URL: https://www.drugs.ie/synthetic_opioid_preparation/
HSE drugs.ie. (2023) Drug trend updates and warnings. URL: https://www.drugs.ie/drugs_info/drug_trend_updates...
[Oireachtas] Dáil Éireann debate. Questions 462 – Health services [opioid overdoses] [50594/23]. (21 Nov 2023)
HSE drugs.ie. (2024) HSE webinar: Safeguarding communities against nitazenes. Health Service Executive.
Scottish Drugs Forum. (2023) On alert: New opioids and benzos in Scotland’s drugs supply (SDF Webinar). Scottish Drugs Forum.
[Irish Examiner] , Dunphy, Liz Cannabis users spiked with heroin while dealers offer free cocaine to expand their market. (18 Nov 2024)
[Irish Times] , Wilson, Jade Cluster of overdoses linked to opiate nitazene ‘came out of the blue’ - HSE clinician. (27 Aug 2024)
[RTE News] Inmates' health monitored after suspected overdoses at Portlaoise Prison. (14 Aug 2024)
[Irish Prison Service] Irish Prison Service issues nationwide prison drug alert. (19 Jul 2024)
[Irish Examiner] , Murphy, Ann Prisoners hand in hundreds of nitazene tablets following inmate death. (19 Jul 2024)
[HSE drugs.ie] HSE Risk Communication - Monitoring Emerging Overdose Situation. (14 Jun 2024)
[Irish Examiner] , O'Keeffe, Cormac Drug dealers 'testing' heroin market with dangerous synthetics. (22 Feb 2024)
[Irish Times] , Kelleher, Olivia HSE issues alert about potent synthetic opioid being sold as heroin in Dublin and Cork. (03 Feb 2024)
[thejournal.ie] , Duffin, Tony Each fatal drug overdose is a preventable death. (20 Jan 2024)
[Irish Times] , Kelleher, Olivia ‘High-risk’ synthetic opioid being sold in Dublin and Cork as heroin, HSE warns. (13 Jan 2024)
[thejournal.ie] Drugs at centre of recent Dublin overdose cluster purchased 'across one strip of the city'. (21 Dec 2023)
[Health Service Executive] HSE risk communication - HSE monitoring emerging overdose situation in Cork City region. (08 Dec 2023)
[thejournal.ie] , Ryan, Órla A potent synthetic opioid was found in the heroin that caused overdoses, but what are nitazenes? (15 Nov 2023)
Health Service Executive. [Health Service Executive] Nitazenes detected in heroin samples related to Dublin overdose cluster. (11 Nov 2023)
[Health Service Executive] HSE issues warning to heroin users following cluster of overdoses in Dublin. (09 Nov 2023)