The following information was compiled in August 2024 and is subject to change as new research is conducted and as new information becomes available:

Description: Methylenedioxynitazene is a novel synthetic opioid bearing structural similarity to other nitazene analogues (e.g., etonitazene, isotonitazene) where the ethoxy group is replaced with a 3,4-methylenedioxy ring. Methylenedioxynitazene was first identified in April 2024 by our laboratory and was confirmed after acquiring standard reference material.

Sample Source: St. Charles County Police Department (O’Fallon, MO)

Sample Appearance: Tan powder

Pharmacology: The activity and potency of methylenedioxynitazene have not been studies.

Toxicology: Methylenedioxynitazene has been identified in two toxicology cases to date at the CFSRE.

Drug Materials: Methylenedioxynitazene has been detected in one drug material to date at the CFSRE.

Demographics / Geographics: Toxicology cases originated from the United Kingdom and the drug material originated from Missouri. Methylenedioxynitazene was found alongside other nitazene analogues (e.g., N-desethyl isotonitazene, N-pyrrolidino protonitazene) and traditional opioids (e.g., fentanyl, heroin).

Legal Status: Methylenedioxynitazene is not explicitly scheduled in the United States.

Class:Opioid Appearance:Tan Powder

Formula:C21H24N4O4

MW:369.4 [M+]:396

[M+H]+:397.1870

IUPAC:2-[2-(1,3-benzodioxol-5-ylmethyl)-5-nitro-benzimidazol-1-yl]-N,N-diethyl-ethanamine

Report Date:August 29, 2024