Bade, Richard and Nadarajan, Dhayaalini and Driver, Erin M and Halden, Rolf U and Gerber, Cobus and Krotulski, Alex and Hall, Wayne and Mueller, Jochen F (2024) Wastewater-based monitoring of the nitazene analogues: First detection of protonitazene in wastewater. The Science of the Total Environment, 920, 170781. https://doi.org/10.1016/j.scitotenv.2024.170781.
External website: https://www.sciencedirect.com/science/article/pii/...
Synthetic opioids, particularly the nitazene analogues class, have become a public health concern due to their high potency. Wastewater-based epidemiology can detect community use of these compounds. The objective of this work was to detect nitazene analogues in wastewater from samples collected from eight sites in the United States. Influent wastewater samples were collected from eight sites in seven states (Arizona, Oregon, New Mexico, Illinois, New Jersey, Washington and Georgia) in the United States. Samples were collected from each site on three days between 27 December 2022 and 4 January 2023, acidified on collection, stored frozen and shipped to Arizona State University (Tempe, AZ) for sample processing. Samples were then shipped to The University of Queensland (Brisbane, Australia) for sample analysis. Protonitazene was found in samples collected from two sites in Washington and Illinois. The concentration was estimated up to 0.5 ng/L, with estimated excreted mass loads up to 0.3 mg/day/1000 people. This work has shown that it is possible to detect nitazene analogues in wastewater using a combination of sample pre-concentration and sensitive instrumentation, thereby further expanding the utility of wastewater-based epidemiology.
E Concepts in biomedical areas > Pharmacology and toxicology
HA Screening, identification, and diagnostic method > Physical / medical screening, assessment and diagnostic method
J Health care, prevention, harm reduction and treatment > Identification and screening > Identification and screening for substance use
VA Geographic area > United States
Repository Staff Only: item control page