Walton, Sara E and Roberts, Dakota and Altomare-Jarczyk, Cole and Edelmann, Abby and Davis, Jamie and Dennehy, Mary and Quinter, Alexis D and DeBord, Joshua and Green, Traci C and Logan, Barry K and Krotulski, Alex J (2024) 5-Methyl Etodesnitazene — NPS Discovery new drug monograph. United States: Center for Forensic Science Research and Education.
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The following information was compiled in August 2024 and is subject to change as new research is conducted and as new information becomes available:
Description: 5-Methyl etodesnitazene is a novel synthetic opioid bearing structural resemblance to etonitazene, etodesnitazene, and other nitazene analogues. 5-Methyl etodesnitazene was first detected in January 2024 by our laboratory and was confirmed in comparison to standard reference material.
Sample Source: AIDS Project of Southern Vermont In Collaboration with StreetCheck
Sample Appearance: White powder
Pharmacology: In vitro pharmacological data available for 5-methyl etodesnitazene show that this drug is an active opioid and is approximately 10x less potent than etonitazene, its 5-NO2 counterpart.
Toxicology: 5-Methyl etodesnitazene has been identified in two toxicology cases to date at the CFSRE.
Drug Materials: 5-Methyl etodesnitazene has been detected in one drug material to date at the CFSRE.
Demographics / Geographics: Drug material originated from Vermont and toxicology cases originated from North Carolina and Connecticut. 5-Methyl etodesnitazene was identified alongside fentanyl, NPS benzodiazepines (e.g., bromazolam), and other nitazene analogues (e.g., metonitazene).
Legal Status: 5-Methyl etodesnitazene is not currently scheduled in the United States.
Class: Opioid
Appearance: White powder
Formula: C23H31N3O
MW: 365.5
[M+]: 365
[M+H]+: 366.2540
IUPAC: 2-[2-[(4-ethoxyphenyl)methyl]-5-methyl-benzimidazol-1-yl]-N,N-diethyl-ethanamine
Report Date: August 26, 2024
B Substances > New (novel) psychoactive substances > Synthetic opioids > Benzimidazole, Nitazenes, Brorphine
E Concepts in biomedical areas > Pharmacology and toxicology
J Health care, prevention, harm reduction and treatment > Risk and needs assessment > Risk assessment
VA Geographic area > United States
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