This report explores the intricate relationship between economic recessions and illicit drug use through an in-depth scoping review of the literature. Unravelling complexities among demographics and drug types, this analysis sheds light on potential impacts of economic downturns, suggesting that young and already socioeconomically vulnerable population groups appear to be most affected during economic downturns. Among young adults, several studies indicate that the use of cannabis may increase during economic downturns. In addition, there are indications that transitioning to more problematic patterns of drug use, such as from smoking or snorting to injecting, may also increase during times of economic turmoil.