In an effort to address the opioid epidemic, a prominent goal of current research is to identify alternative treatments with equal or better benefits for pain while avoiding potential unintended consequences that could result in harms.

A systematic review assessing the effectiveness and harms of plant-based treatments for chronic pain conditions is underway. The review will be "living" in the sense that it will identify and synthesize recently published literature on an ongoing basis. For the purposes of this review, plant-based compounds (PBCs) included are those that are similar to opioids in effect and that have the potential for addiction, misuse, and serious adverse effects; other PBCs such as herbal treatments are not included. The intended audience includes policy and decision makers, funders and researchers of treatments for chronic pain, and clinicians who treat chronic pain.

The quarterly progress reports present the accumulating evidence and are updated on a regular basis. They include a description of the available studies and an appraisal of study quality.

For the latest report, click 'download full content' on the project website. For previous reports, scroll down the main page.