This article outlines the prevalence of zopiclone misuse in clients attending a methadone maintenance programme. Using an analysis of urine samples from 158 clients, the authors provide a profile of zopiclone misusers, including details of demographics, drug history, viral status, recent urinalysis results and opinions on zopiclone. Benzodiazepines were the most popular drug of misuse with zopiclone followed by heroin/opiates. The authors conclude that Zopiclone is being misused by drug users in Dublin in the context of many other drugs and they recommend the restriction of zopiclone prescriptions to drug users.