Advisory Council on the Misuse of Drugs. (2025) Synthetic cathinones: an updated harms assessment. London: Advisory Council on the Misuse of Drugs.
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Synthetic cathinones are human-made stimulants chemically related to cathinone, one of the naturally occurring psychoactive principals that can be extracted from the khat plant (Catha edulis) (ACMD, 2010). The chewing of khat for its stimulant effects has been common for centuries amongst communities from the horn of Africa and the Arabian Peninsula, where the plant is endemic. However, this practice has not become popular in Europe due to the challenges in obtaining the fresh product, the duration of chewing needed to obtain a psychoactive effect and the bitter taste of the leaves. It is also easier and less expensive to manufacture synthetic cathinones in a laboratory than to extract psychoactive compounds directly from the khat plant.
B Substances > New (novel) psychoactive substances > Synthetic cathinones
E Concepts in biomedical areas > Pharmacology and toxicology
J Health care, prevention, harm reduction and treatment > Risk and needs assessment > Risk assessment
MM-MO Crime and law > Substance use laws > Drug laws
P Demography, epidemiology, and history > Population dynamics > Substance related mortality / death
VA Geographic area > Europe > United Kingdom
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