In the present report, the Special Rapporteur on the right of everyone to the enjoyment of the highest attainable standard of physical and mental health, Tlaleng Mofokeng, explores how harm reduction relates to both drug use and drug use disorders, as well as to drug laws and policies, aiming to analyse and address the related outcomes that adversely impact the enjoyment of the right to health. In doing so, she focuses on drugs whose production, distribution and consumption have been subject to control under the international drug control conventions, including how the approach to such control has negatively affected the availability, accessibility, acceptability and quality of certain drugs used as medicines.