Home > Factors associated with opioid overdose after an initial opioid prescription.

Weiner, Scott G and El Ibrahimi, Sanae and Hendricks, Michelle A and Hallvik, Sara E and Hildebran, Christi and Fischer, Michael A and Weiss, Roger D and Boyer, Edward W and Kreiner, Peter W and Wright, Dagan A and Flores, Diana P and Ritter, Grant A (2022) Factors associated with opioid overdose after an initial opioid prescription. JAMA Network Open, 5, (1), e2145691. 10.1001/jamanetworkopen.2021.45691.

External website: https://jamanetwork.com/journals/jamanetworkopen/f...

Question: What factors are associated with an increased risk for opioid overdose after the initial opioid prescription to a previously opioid-naive individual?

Findings: In this cohort study of 236 921 individuals who received a first opioid prescription, 667 experienced an incident opioid overdose. Patient risk factors included being aged 75 years or older, being male, receiving Medicaid or Medicare Advantage coverage, having a comorbid substance use disorder or depression, and having medical comorbidities. Prescription-related risk factors included an initial prescription of oxycodone or tramadol, concurrent use of benzodiazepines, and filling opioid prescriptions from 3 or more pharmacies.

Meaning: Findings from this study suggest that several patient- and prescription-related risk factors are associated with opioid overdose; prescribers, researchers, policy makers, and insurers can apply this information to guide opioid counseling and monitoring, develop clinical decision-making tools, and provide additional opioid prevention and treatment resources to individuals who are at greatest risk for opioid overdose.

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