Home > Effects of cannabinoid exposure during neurodevelopment on future effects of drugs of abuse: a preclinical perspective.

Farrelly, Aaron Mark and Vlachou, Styliani (2021) Effects of cannabinoid exposure during neurodevelopment on future effects of drugs of abuse: a preclinical perspective. International Journal of Molecular Sciences, 22, (18), . https://doi.org/10.3390/ijms22189989.

External website: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84721...

The endocannabinoid system plays a central role in the earliest stages of embryonic, postnatal and adolescent neurodevelopment. Aberrant activity of this system at key developmental phases has been shown to affect neural development. The aim of this review is to synthesise and analyse preclinical insights within rodent populations, focusing on the effects that perinatal (embryonic, gestational and early postnatal developmental stages) and adolescent (postnatal day 21-60) cannabinoid exposure impose across time on the subsequent activity of various drugs of abuse. Results in rodents show that exposure to cannabinoids during the perinatal and adolescent period can lead to multifaceted behavioural and molecular changes. In the perinatal period, significant effects of Δ-THC exposure on subsequent opiate and amphetamine reward-related behaviours were observed primarily in male rodents. These effects were not extended to include cocaine or alcohol. In adolescence, various cannabinoid agonists were used experimentally. This array of cannabinoids demonstrated consistent effects on opioids across sex. In contrast, no significant effects were observed regarding the future activity of amphetamines and cocaine. However, these studies focused primarily on male rodents. In conclusion, numerous gaps and limitations are apparent in the current body of research. The sparsity of studies analysing the perinatal period must be addressed. Future research within both periods must also focus on delineating sex-specific effects, moving away from a male-centric focus. Studies should also aim to utilise more clinically relevant cannabinoid treatments.


Item Type
Article
Publication Type
Irish-related, Open Access, Review, Article
Drug Type
Cannabis
Intervention Type
Prevention, Harm reduction
Date
15 September 2021
Identification #
https://doi.org/10.3390/ijms22189989
Publisher
MDPI
Volume
22
Number
18
EndNote

Repository Staff Only: item control page