Skip Page Header

Home > Efficacy and safety of cannabidiol plus standard care vs standard care alone for the treatment of emotional exhaustion and burnout among frontline health care workers during the COVID-19 pandemic: a randomized clinical trial.

Crippa, José Alexandre S and Zuardi, Antonio W and Guimarães, Francisco S and Campos, Alline Cristina and de Lima Osório, Flávia and Loureiro, Sonia Regina and Dos Santos, Rafael G and Souza, José Diogo S and Ushirohira, Juliana Mayumi and Pacheco, Julia Cozar and Ferreira, Rafael Rinaldi and Mancini Costa, Karla Cristinne and Scomparin, Davi Silveira and Scarante, Franciele Franco and Pires-Dos-Santos, Isabela and Mechoulam, Raphael and Kapczinski, Flávio and Fonseca, Benedito A L and Esposito, Danillo L A and Pereira-Lima, Karina and Sen, Srijan and Andraus, Maristela Haddad and Hallak, Jaime E C (2021) Efficacy and safety of cannabidiol plus standard care vs standard care alone for the treatment of emotional exhaustion and burnout among frontline health care workers during the COVID-19 pandemic: a randomized clinical trial. JAMA Network Open, 4, (8), e2120603. doi: 10.1001/jamanetworkopen.2021.20603.

External website: https://jamanetwork.com/journals/jamanetworkopen/f...

Question: Is cannabidiol (CBD) therapy capable of reducing emotional exhaustion and burnout symptoms among frontline health care professionals working with patients with COVID-19?

Findings: In this randomized clinical trial of 120 frontline health care professionals, emotional exhaustion scores were reduced among participants receiving CBD plus standard care compared with those receiving standard care alone. Five participants who received CBD plus standard care experienced serious adverse events, with full recovery after discontinuation.

Meaning: The study’s findings suggest that CBD may act as an effective agent for the reduction of emotional exhaustion and burnout symptoms among frontline health care professionals, although it is necessary to balance the benefits with potential undesired effects when making decisions regarding the use of CBD.


Repository Staff Only: item control page