Homelessness greatly magnifies morbidity and mortality and worsens preventable health and social inequities. We present evidence on a wide range of interventions targeting homelessness: permanent supportive housing (PSH); income assistance; standard case management and peer support; mental health interventions such as assertive community treatment (ACT), intensive case management (ICM), critical time intervention (CTI), and injectable antipsychotics; and substance use interventions such as supervised consumption facilities, managed alcohol programmes and pharmacological interventions for opioid use disorders.

This systematic review and meta-analysis examines the effects of a broad range of interventions on housing stability, mental health, quality of life, substance use, hospitalisations and health service utilisation, as well as employment and income among individuals with lived experience of homelessness.