Data from the National Vital Statistics System, Mortality

• From 2009 through 2019, the rate of overdose deaths involving both cocaine and opioids increased at a faster pace than the rate of overdose deaths with cocaine but no opioids.
• In 2019, 76% of overdose deaths involving cocaine also involved an opioid; the percentage varied by region, from 83% in the Northeast to 63% in the West.
• From 2009 through 2016, the rate of overdose deaths involving psychostimulants but no opioids was higher than the rate for deaths involving both drugs; from 2017 through 2019, the pattern reversed with a higher rate for deaths involving both psychostimulants and opioids.
• In 2019, 54% of overdose deaths involving psychostimulants also involved an opioid; the percentage varied by region, from 80% in the Northeast to 44% in the West.

Deaths from drug overdose continue to contribute to the public health burden in the United States (1). The increase in the rate of drug overdose deaths involving cocaine and psychostimulants has been well-documented in recent years (1–4). This NCHS Data Brief provides additional information on drug overdose deaths involving cocaine and other psychostimulants (drugs such as methamphetamine, amphetamine, and methylphenidate) by examining the concurrent involvement of opioids. Trends from 2009 through 2019 and differences by census region in 2019 are presented.