Home > Dependence and withdrawal associated with some prescribed medicines An evidence review.

Taylor, Stephen and Annand, Fizz and Burkinshaw, Peter and Greaves, Felix and Kelleher, Michael and Knight, Jonathan and Perkins, Clare and Tran, Anh and White, Martin and Marsden, John [Public Health England] . (2019) Dependence and withdrawal associated with some prescribed medicines An evidence review. London: Public Health England. 152 p.

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In 2017, the minister for public health and primary care commissioned Public Health England (PHE) to identify the scale, distribution and causes of prescription drug dependence, and what might be done to address it. 

The review covered adults (aged 18 and over) and 5 classes of medicines:

  • benzodiazepines (mostly prescribed for anxiety)
  • z-drugs (sleeping tablets with effects similar to benzodiazepines)
  • gabapentin and pregabalin (together called gabapentinoids and used to treat epilepsy, neuropathic pain and, in the case of pregabalin, anxiety)
  • opioids for chronic non-cancer pain
  • antidepressants
Item Type:Evidence resource
Publication Type:Review
Drug Type:CNS depressants, New psychoactive substance, Prescription/Over the counter
Intervention Type:AOD disorder harm reduction
Source:Public Health England
Date:September 2019
Pages:152 p.
Publisher:Public Health England
Place of Publication:London
EndNote:View
Related URLs:
Subjects:B Substances > Sedatives or tranquillisers (CNS depressants)
B Substances > Sedatives or tranquillisers (CNS depressants) > Benzodiazepine
B Substances > Opioids (opiates) > Opioid product > Codeine
B Substances > New (novel) psychoactive substances > Gabapentinoids GABA (Pregabalin / Gabapentin)
E Concepts in biomedical areas > Substance by legal status > Prescription drug (medicine / medication)
G Health and disease > Substance use disorder > Drug use > Drug dependence
J Health care, prevention and rehabilitation > Patient care management
T Demographic characteristics > Doctor
VA Geographic area > Europe > United Kingdom

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