Home > Methadone maintenance treatment and mortality in people with criminal convictions: a population-based retrospective cohort study from Canada.

Russolillo, Angela and Moniruzzaman, Akm and Somers, Julian M [PLOS One] . (2018) Methadone maintenance treatment and mortality in people with criminal convictions: a population-based retrospective cohort study from Canada. PLoS ONE, 15 (7 e1002625) https://doi.org/10.1371/journal.pmed.1002625

URL: http://journals.plos.org/plosmedicine/article?id=1...

Why was this study done?
• Individuals with criminal histories experience high rates of opioid dependence and premature mortality.
• Deaths caused by opioids are rising acutely and offenders are at risk.
• Adherence to opioid substitution treatments (OSTs), such as methadone, has been shown to reduce the risk of death during custody and immediately following release.
• Little is known about the long-term association between methadone adherence and mortality.

What did researchers do and find?
• This study integrated population-level data including prescriptions, convictions, and deaths in British Columbia (BC), Canada spanning 1998–2015.
• We examined the risk of all-cause and cause-specific death among 14,530 people with criminal convictions who had been prescribed methadone.
• Overall and cause-specific mortality rates were compared between periods when methadone was and was not dispensed.
• Periods when methadone was dispensed were associated with lower risk of mortality, including overdose fatalities, after controlling for covariates.

What do these findings mean?
• Practices to increase methadone adherence among opioid-dependent offenders are required and may reduce overdose-related, as well as other causes of, premature death.


Item Type:Evidence resource
Publication Type:Review
Drug Type:Opioid
Intervention Type:AOD disorder, AOD disorder harm reduction
Source:PLOS One
Date:July 2018
Volume:15
Number:7 e1002625
EndNote:View
Subjects:B Substances > Opioids (opiates) > Opioid product > Methadone
G Health and disease > Substance use disorder > Drug use > Drug intoxication > Poisoning (overdose)
HJ Treatment method > Substance disorder treatment method > Substance replacement method (substitution) > Methadone maintenance
MM-MO Crime and law > Criminal penalty > Community service (penalty) > Probation or parole
P Demography, epidemiology, and history > Population dynamics > Substance related mortality / death
T Demographic characteristics > Prison Inmate (prisoner)
T Demographic characteristics > Offender
VA Geographic area > Canada

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