This report was developed as part of an initiative of the U.S. Department of Health and Human Services (HHS) Office on Women’s Health (OWH) to examine prevention, treatment, and recovery issues for women who misuse opioids, have opioid use disorders (OUDs), and/or overdose on opioids. Since this work began in March 2015, OWH developed a White Paper: Opioid Use, Misuse, and Overdose in Women and convened  a national meeting in September 2016 and a Region I (New England) meeting in October 2016 to discuss  these critical issues. This Report highlights the key background and findings from the white paper, provides a summary of the national meeting, and concludes with a section focused on findings and takeaways from both the national and regional meetings.