Home > LAAM maintenance vs methadone maintenance for heroin dependence.

Clark, Nicolas C. and Lintzeris, Nicholas and Gijsbers, Alan and Whelan, Greg and Dunlop, Adrian and Ritter, Alison and Ling, Walter W. [The Cochrane Library] . (2002) LAAM maintenance vs methadone maintenance for heroin dependence. John Wiley & Sons, Ltd. Cochrane Database of Systematic Reviews (2) DOI: 10.1002/14651858.CD002210

URL: https://www.cochranelibrary.com/cdsr/doi/10.1002/1...

Objective: To compare the efficacy and acceptability of LAAM maintenance with methadone maintenance in the treatment of heroin dependence.

Opiate drugs are used to help people reduce their dependence on heroin (an opiate drug). Methadone needs daily doses, but the effects do not last 24 hours for many people. A dose of LAAM (levomethadyl acetate hydrochloride) works for two or three days. LAAM is not as widely available internationally as methadone, and may be withdrawn from the market because of concerns about life-threatening effects on the heart. The review found that LAAM is more effective than methadone at reducing heroin dependence, but there was not enough evidence from trials to draw conclusions about safety.


Item Type:Evidence resource
Publication Type:Review
Drug Type:Opioid
Intervention Type:AOD disorder drug therapy
Source:The Cochrane Library
Date:2002
Publisher:John Wiley & Sons, Ltd
Number:2
EndNote:View
Accession Number:HRB (Electronic Only)
Subjects:J Health care, prevention and rehabilitation > Health care administration > Health care quality control
HJ Treatment method > Treatment outcome
B Substances > Opioids (opiates) > Heroin
HJ Treatment method > Substance disorder treatment method > Substance replacement method (substitution)
B Substances > Opioids (opiates)
HJ Treatment method > Substance disorder treatment method > Substance replacement method (substitution) > Methadone maintenance
HJ Treatment method > Substance disorder treatment method > Substance disorder drug therapy

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