Problematic substance use continues to be a major social issue within society, with increases in consumption and use of drugs, increases in drug related deaths and increases in dependency on existing and emerging substances. International and national drug policy is also heavily contested, with pressure to develop harm reduction based policy rather than the more punitive and abstinence based approach. This module will explore current and emerging issues in relation to women and substance use, within the Irish and international context. Women’s problematic substance use is explored in the context of the inter-related and sometimes unique factors that may impact on women’s substance use trajectories, with a particular focus on effective intervention, and innovation in practice and policy responses. The role and impact of intimate partner violence, sex working, trauma histories and pregnancy and mothering on women’s substance use are considered and explored. The development and provision of innovative responses and interventions are presented, together with the implications for drug and social policy.