Home > The natural history of HIV infection in women attending a sexually transmitted disease clinic in Dublin.

Mulcahy, Fiona and Kelly, Grainne and Tynan, M (1994) The natural history of HIV infection in women attending a sexually transmitted disease clinic in Dublin. Genitourinary Medicine , 70 , pp. 81-83.

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This paper aimed to determine the progression rates to AIDS in women in Dublin. For this study 109 HIV-1 seropositive women who presented to the Department of Genitourinary Medicine, St. James's Hospital, Dublin, were included in a retrospective analysis. Of these 101 (93%) were intravenous drug users (IVDUs), 7 were heterosexual partners of IVDUs and one had a hetero-sexual partner of no known risk group. Forty-four women (40%) had had 57 children since the time of their first known HIV seropositive test. Progression rates from CDC Stage 11/111 to AIDS are computed and progression curves are generated according to the Kaplan-Meier method using the Statistical Analysis Software (SAS). Results showed that the estimated cumulative progression rate at 5 years was 24% (SE 6.6%). Seventeen out of 109 (15.6%) developed AIDS. The mean follow up time was 2.8 years (SE 0.2). The prevalence of oesophageal candidiasis taking development of AIDS as the point in time was 9 out of 17 (53%), of Mycobacterium hominis infection (TB) 5 (29%) and of Pneumocystis carcinii pneumonia (PCP) 2 (12%). There was no statistical difference in progression rates to AIDS between those women who had children after becoming infected versus those who had none. The results show that progression rates to AIDS in Irish women is higher than reported in other studies of homosexual or bisexual men, but is similar to rates estimated for both male and female IVDUs. Oesophageal candidiasis is the commonest presenting AIDS diagnosis followed by TB, while PCP is rare, contrary to the findings of similar studies in the USA.


Item Type:Article
Date:1994
Page Range:pp. 81-83
Publisher:BMJ Publishing
Volume:70
Notes:Contains bibliographic references, figures and tables. Journal now called Sexually Transmitted Infections
EndNote:View
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Subjects:VA Geographic area > Europe > Ireland > Dublin
T Demographic characteristics > Homosexual, gay, bisexual or lesbian, LGBTI
T Demographic characteristics > Intravenous / injecting drug user
T Demographic characteristics > Woman (women / female)
F Concepts in psychology > Specific attitude and behaviour > risk-taking behaviour
G Health and disease > Disorder by cause > Communicable disease > HIV
J Health care, prevention and rehabilitation > Health related prevention > Health information and education > Communicable disease control > Safe sex

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