Home > Report to the National Advisory Committee on Drugs on "use of lofexidine in the management of opiate dependence syndrome".

National Medicines Information Centre. (2002) Report to the National Advisory Committee on Drugs on "use of lofexidine in the management of opiate dependence syndrome". Dublin: Stationery Office.

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Lofexidine is a structural analogue of clonidine and reduces withdrawal symptoms for opiate dependent patients. The activity of lofexidine is not prevented by naloxone. This review evaluates the usefulness of lofexidine as a treatment option in the management of opiate dependency. All the available data in the field was consulted and experts in Ireland were contacted. Clinical trials for lofexidine showed that it appeared to be at least as effective as clonidine and reducing doses of methadone for use in the treatment of opiate withdrawal. The evaluation also showed that lofexidine was as effective as clonidine for managed withdrawal without risks of hypertension. Workers in the field have suggested that lofexidine is more effective in younger patients and those who have a shorter, less entrenched history of opiate use. The review suggests that lofexidine may be useful as an additional treatment for managed opiate withdrawal.


Date:2002
Call No:REF, NACD
Pages:36 p.
Publisher:Stationery Office
Corporate Creators:National Medicines Information Centre
Place of Publication:Dublin
ISBN:0-7557-1784-8
Keywords:AOD withdrawal syndrome, AODD treatment, harm reduction, harm reduction policy, heroin, Ireland, lofexidine, opiate withdrawal agents
Notes:Includes tables, bibliographic references and questionnaire.
EndNote:View
Accession Number:HRB 2175 (Available), HRB 2176 (Available), HRB 2174 (Available)
Related URLs:
Subjects:VA Geographic area > Europe > Ireland
G Health and disease > Substance use disorder > Drug use > Drug withdrawal syndrome
HJ Treatment method > Substance disorder treatment method > Substance replacement method (substitution)
B Substances > Opioids (opiates)
MP-MR Policy, planning, economics, work and social services > Policy > Policy on substance use > Harm reduction policy

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