Home > Optimal provision of opiate substitution therapy and needle and syringe programmes: a multi-method realist evaluation.

McCulloch, Peter and Shaw, April and Gilchrist, Gail and Matheson, Catriona and Maxwell, Margaret and Neale, Joanne and Myring, Gareth and McLeod, Hugh and Hickman, Matt and Vickerman, Peter and Munro, Alison and MacGillivray, Steve (2025) Optimal provision of opiate substitution therapy and needle and syringe programmes: a multi-method realist evaluation. Health Technology Assessment, 29, (64), pp. 1-118. https://doi.org/10.3310/HGDS4449.

External website: https://www.journalslibrary.nihr.ac.uk/hta/HGDS444...

BACKGROUND: The barriers and facilitators to engagement with Opiate Substitute Treatment and Needle and Syringe Provision need to be better understood to develop interventions to attract people into services.

OBJECTIVE(S): We conducted a multi-method realist evaluation to generate an in-depth theory of the factors that influence the optimal provision of services in terms of access, engagement, retention and successful exit.

DESIGN: Multi-method involving an online survey of United Kingdom drug and alcohol service commissioning leads and a meta-synthesis of qualitative literature (phase 1) to facilitate the development of an initial theory of optimal provision; and, in phase 2, a realist evaluation to test and refine the initial theory, involving in-depth interviews across three United Kingdom sites, with service commissioners, managers, staff and service users. We used routine treatment and staffing data to estimate the additional staff costs of implementing optimal service provision within one context of our refined theory.

RESULTS: Findings indicated that optimal provision could be understood with reference to five main contexts [(1) agency and empowerment, (2) self-esteem and respect, (3) knowledge and communication, (4) goals, needs and preferences and (5) resources and demands]. The analysis suggested that optimal provision could be facilitated via specific mechanisms of action, operating at the 'Systems level' (policy, legislation and funding) and 'Service level' (delivery of services, service pathways, staff roles and responsibilities and organisational culture). Our analysis also identified the potential importance of independent 'mediating mechanisms' (e.g. confidence, trust and self-efficacy) which can operate to increase the likelihood of successful service outcomes. A costing analysis estimated the costs associated with a smaller caseload for shared care workers and the implementation of a salary increment scheme at one of the study sites.

LIMITATIONS: The survey sample size limited generalisability. There was a limited number of United Kingdom studies within the meta-synthesis. The findings of the realist evaluation highlight that provision was not optimised in the observed sites, limiting examples of best practice. However, the conceptual theory of optimal provision can direct future research to facilitate the development and implementation of optimal policy and practice.

CONCLUSIONS: We have provided a rich understanding of the contexts, mechanisms and actions by which optimal delivery of Opiate Substitute Treatment and Needle and Syringe Provision services may increase the likelihood of successful service provision. A multiagency approach applying various mechanisms within the various contexts of optimal provision may need to be implemented to optimise the provision.

FUTURE WORK: Future research should focus on the development of a multiple-system toolkit or intervention to help drug services to implement optimal provision. More research is also needed to assess, the barriers and facilitators, that vulnerable underserved population and people from minority ethnic groups may face, and the mechanisms to improve provision for these populations.


Item Type
Article
Publication Type
International, Open Access, Review, Article
Drug Type
Substances (not alcohol/tobacco), CNS stimulants, Cocaine, Opioid
Intervention Type
Harm reduction
Date
December 2025
Identification #
https://doi.org/10.3310/HGDS4449
Page Range
pp. 1-118
Publisher
National Institute for Health Research
Volume
29
Number
64
EndNote
Subjects
B Substances > Opioids (opiates)
B Substances > Opioids (opiates) > Opioid product > Buprenorphine / Suboxone
B Substances > Opioids (opiates) > Opioid product > Methadone
G Health and disease > Disease by cause (Aetiology) > Needle (sharing / injecting)
HJ Treatment or recovery method > Substance disorder treatment method > Substance disorder drug therapy (pharmacological treatment)
HJ Treatment or recovery method > Substance disorder treatment method > Substance replacement method (substitution)
HJ Treatment or recovery method > Substance disorder treatment method > Substance replacement method (substitution) > Opioid agonist treatment (methadone maintenance / buprenorphine)
J Health care, prevention, harm reduction and treatment > Harm reduction > Substance use harm reduction
J Health care, prevention, harm reduction and treatment > Health related issues > Health information and education > Communicable / infectious disease control > Needle syringe distribution and exchange
J Health care, prevention, harm reduction and treatment > Patient / client care management
J Health care, prevention, harm reduction and treatment > Treatment and maintenance > Treatment factors
J Health care, prevention, harm reduction and treatment > Treatment and maintenance > Patient / client attitude toward treatment (experience)
J Health care, prevention, harm reduction and treatment > Treatment and maintenance > Provider / worker / staff attitude toward treatment
MP-MR Policy, planning, economics, work and social services > Policy > Policy on substance use > Harm reduction policy
MP-MR Policy, planning, economics, work and social services > Programme planning, implementation, and evaluation > Programme and budget analysis (cost benefit)
VA Geographic area > International

Repository Staff Only: item control page