This report shows that the production and trafficking of methamphetamine in Shan State, Myanmar, have significantly increased since 2021. Thailand remained the main transit and destination point for methamphetamine trafficked from Myanmar and recorded the largest quantity of methamphetamine seizures in the region. The report highlights the evolving nature of transnational drug trafficking groups operating in East and Southeast Asia. These groups have demonstrated remarkable agility in reacting to law enforcement pressure, as shown by the spread of production sites for ketamine and related precursor chemicals.