The following information was compiled in August 2024 and is subject to change as new research is conducted and as new information becomes available:

Description: ortho-Methyl boc-4-AP is a synthetic opioid precursor that can be used in the synthesis of ortho-methylfentanyl. ortho-Methyl boc-4-AP bears structural similarity to N-boc 4-AP and other related fentanyl precursors. ortho-Methyl boc-4-AP was first detected in May 2024 by our laboratory and was confirmed through comprehensive chemical analysis.

Sample Source: Reuters (Media Agency)

Sample Appearance: White powder

Pharmacology: Based on our understanding of fentanyl analogue precursor pharmacology, it is hypothesized that ortho-methyl boc-4-AP is not an active opioid or exhibits very low potency compared to fentanyl and other synthetic opioids. Ortho-methyl boc-4-AP can be used to produce ortho-methylfentanyl, an active mu opioid agonist with potency similar to that of fentanyl.

Toxicology: ortho-Methyl boc-4-AP has not been identified in toxicology cases to date at the CFSRE.

Drug Materials: ortho-Methyl boc-4-AP has been detected in one drug material to date at the CFSRE.

Demographics / Geographics: The drug material originated from China. Ortho-Methyl boc-4-AP was detected in the absence of other substances.

Legal Status: ortho-Methyl boc-4-AP is not explicitly scheduled in the United States.

Class: Opioid
 Appearance: White powder
 Formula: C17H26N2O2
 MW: 290.4
 [M+]: 290
 [M+H]+: 291.2067
 IUPAC: tert-butyl 4-(2-methylanilino)piperidine-1-carboxylate
 Report Date: August 30, 2024