Summarizes findings and themes discussed at the Cannabis, Mental Health and Substance Use Health Research Knowledge Exchange Event we cohosted with the Mental Health Commission of Canada. With funding from Health Canada, our two organizations supported about 70 research teams who explored the potential benefits, harms and risks cannabis poses to substance use health and mental health. The event brought together the research teams to share their project results, observations and experiences. Topics included the effects of legalization on perceptions and patterns of cannabis use, the impacts of legalization on mental health and wellness, the lived experiences of equity-deserving populations, and more. Also discusses recommendations for future research, policy and practice.