Home > The IARC perspective on alcohol reduction or cessation and cancer risk.

Gapstur, Susan M and Bouvard, Véronique and Nethan, Suzanne T and Freudenheim, Jo L and Abnet, Christian C and English, Dallas R and Rehm, Jürgen and Balbo, Silvia and Buykx, Penny and Crabb, David and Conway, David I and Islami, Farhad and Lachenmeier, Dirk W and McGlynn, Katherine A and Salaspuro, Mikko and Sawada, Norie and Terry, Mary B and Toporcov, Tatiana and Lauby-Secretan, Béatrice (2023) The IARC perspective on alcohol reduction or cessation and cancer risk. New England journal of Medicine, 389, (26), pp. 2486-2494. DOI: 10.1056/NEJMsr2306723.

External website: https://www.nejm.org/doi/10.1056/NEJMsr2306723

Globally, ethanol — the principal form of alcohol in alcoholic beverages — is the most widely used psychoactive substance. In 2019, 44% of the global population 15 years of age or older had consumed alcohol in the previous year. The prevalence of alcohol consumption varies considerably according to geographic region, ranging from 4% in the World Health Organization (WHO) Eastern Mediterranean Region to at least 60% in the European, American, and Western Pacific Regions, and is higher among men than among women. 

Global Population Attributable Fractions and Number of New Cancer Cases Attributable to Alcohol Consumption in 2020, According to Cancer Site and Sex. The International Agency for Research on Cancer (IARC) classified alcoholic beverages as carcinogenic to humans (Group 1) on the basis of sufficient evidence of causality for oral, pharyngeal, laryngeal, esophageal (squamous-cell), liver (hepatocellular), colorectal, and breast cancers3-5 (hereafter referred to as alcohol-related cancers)…

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