Home > Prenatal alcohol exposure and early-life adversity: a translational perspective for dissecting compounding impacts.

Holman, Parker J and Raineki, Charlis (2023) Prenatal alcohol exposure and early-life adversity: a translational perspective for dissecting compounding impacts. Alcohol: Clinical and Experimental Research, 47, (12), pp. 2227-2230. https://doi.org/10.1111/acer.15212.

External website: https://onlinelibrary.wiley.com/doi/10.1111/acer.1...

Commentary: Fetal alcohol spectrum disorder (FASD) describes the wide range of physical, physiological, cognitive, and neurobehavioral deficits associated with prenatal alcohol exposure (PAE; Caputo et al., 2016; Lunde et al., 2016; Mattson et al., 2019). Arguably, the most common neurodevelopmental disorder, FASD has a prevalence estimated at 1.1%–5.0% in the United States (May et al., 2018). Importantly, reports from the clinical literature clearly indicate that PAE/FASD carries an increased risk of exposure to adverse and/or stressful environments postnatally (Flannigan et al., 2021; Lebel et al., 2019; Streissguth et al., 2004). Indeed, many individuals with PAE live in unstable family environments, which may include having a parent with an alcohol/substance use disorder, experiencing removal from the home, and/or having multiple foster care placements. Moreover, PAE also carries a higher risk of experiencing later physical and/or sexual abuse when compared to nonexposed individuals (Kambeitz et al., 2019; Streissguth et al., 2004)...

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