This report of the WHO Study Group on Tobacco Product Regulation provides the Director-General with scientifically sound, evidence-based recommendations for Member States about tobacco product regulation. The outcomes and recommendations address emerging issues in tobacco product regulation, such as newer ways in which non-therapeutic nicotine, particularly in nicotine products, is promoted and delivered to people in different age groups.  The five topics addressed in the report, based on the commissioned background papers for the eleventh meeting of the study group, are enumerated below: 

• Additives that facilitate inhalation, including cooling agents, nicotine salts and flavourings (Section 2);
• Synthetic nicotine: science, global legal landscape and regulatory considerations (Section 3);
• Nicotine pouches: characteristics, use, harmfulness and regulation (Section 4);
• Biomarkers of exposure, effect and susceptibility for assessing electronic nicotine delivery devices and heated tobacco products, and their possible prioritization (Section 5) and
• Internet, influencer and social media marketing of tobacco and non-therapeutic nicotine products and associated regulatory considerations (Section 6).