Importance: e-Cigarette use and vaping marijuana (cannabis) are popular among US adolescents. Cannabidiol (CBD) is a compound found in the cannabis plant that has recently increased in use.

Question: What is the prevalence of youths vaping cannabidiol (CBD), and what are the factors associated with this behavior?

Findings: In this cross-sectional study of 28 291 adolescents, the prevalence of vaping CBD was high, particularly among current e-cigarette users and Hispanic and sexual minority populations. Viewing tobacco as harmful was associated with a reduced likelihood of vaping CBD.

Meaning: The findings suggest that tighter CBD regulations to close existing loopholes and evidence-based educational campaigns and interventions are needed to reduce CBD vaping among youths.