Home > Management of acetaminophen poisoning in the US and Canada: a consensus statement.

Dart, Richard C and Mullins, Michael E and Matoushek, Theresa and Ruha, Anne-Michelle and Burns, Michele M and Simone, Karen and Beuhler, Michael C and Heard, Kennon J and Mazer-Amirshahi, Maryann and Stork, Christine M and Varney, Shawn M and Funk, Alexandra R and Cantrell, Lee F and Cole, Jon B and Banner, William and Stolbach, Andrew I and Hendrickson, Robert G and Lucyk, Scott N and Sivilotti, Marco L A and Su, Mark K and Nelson, Lewis S and Rumack, Barry H (2023) Management of acetaminophen poisoning in the US and Canada: a consensus statement. JAMA Network Open, 6, (8), e2327739. doi: 10.1001/jamanetworkopen.2023.27739.

External website: https://jamanetwork.com/journals/jamanetworkopen/f...

Importance: The US and Canada currently have no formal published nationwide guidelines for specialists in poison information or emergency departments for the management of acetaminophen [paracetamol] poisoning, resulting in significant variability in management.

Question: What is the appropriate management of acetaminophen poisoning after acute or repeated ingestion?

Findings: This qualitative study used an expert-derived consensus according to a modified Delphi process to provide explicit clinical guidance on the assessment, management, and treatment of acetaminophen poisoning.

Meaning: These recommendations provide a rationale for current approaches to the management of acetaminophen poisoning.


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