Data from the National Vital Statistics System

• From 2011 through 2021, the age-adjusted rate of overdose deaths involving both cocaine and opioids increased more quickly than the rate of overdose deaths involving cocaine alone.
• In 2021, 78.6% of overdose deaths involving cocaine also involved an opioid, with the percentage varying by Census region, from 73.4% in the West to 84.5% in the Northeast.
• From 2011 through 2016, the rates of overdose deaths involving psychostimulants without opioid involvement were higher than those involving both drugs, but from 2017 through 2021, rates involving both psychostimulants and opioids were higher.
• In 2021, 65.7% of overdose deaths involving psychostimulants also involved an opioid, with the percentage varying by region, from 57.5% in the West to 80.6% in the Northeast.