Over the last thirty-five years, academic researchers in Ireland have consistently demonstrated the relationship between social deprivation and the most severe instances of drug-related harm. More recently, researchers have begun to include the voices of drug users with lived experiences of harm in these discussions. However, these studies have more often tended to focus on drug users' views on alternative drug policy options, rather than their views on the social and economic factors relevant to their experiences of drug-related harm. Therefore, the current study conducted 12 in-depth interviews with drug users experiencing harm in an Irish city, in order to elicit their views on the specific role they believe social and economic factors played in conditioning their later experiences of drug--related harm. The study participants highlight harms experienced in the education system, the family home, and the local community as more relevant to their later experiences of drug-related harm than their social deficits in education, a lack of resources in the local community or in their families. Many participants also discuss meaningful relationships as the last defence against these harms and argue that the loss of such relationships coincided with their most severe incidences of drug-related harm. The study concludes with a discussion of the conceptual framework of structural violence in terms of its potential for interpreting the participants' views and suggests several avenues for further research.