Heikkinen, Milja and Taipale, Heidi and Tanskanen, Antti and Mittendorfer-Rutz, Ellenor and Lähteenvuo, Markku and Tiihonen, Jari (2023) Association of pharmacological treatments and hospitalization and death in individuals with amphetamine use disorders in a Swedish nationwide cohort of 13 965 patients. JAMA Psychiatry, 80, (1), pp. 31-39. doi: 10.1001/jamapsychiatry.2022.3788.
External website: https://jamanetwork.com/journals/jamapsychiatry/fu...
Question: What is the association between pharmacological treatments and hospitalization and mortality outcomes in individuals with amphetamine use disorders?
Findings: In this Swedish nationwide cohort study of 13 965 individuals, lisdexamphetamine was significantly associated with a decrease in risk of hospitalization due to substance use disorder, any hospitalization or death, and all-cause mortality.
Meaning: In this study, lisdexamphetamine was consistently associated with improved outcomes in individuals with amphetamine use disorders, while other pharmacological treatments were not, encouraging the conduct of randomized clinical trials.
HJ Treatment or recovery method > Substance disorder treatment method > Substance disorder drug therapy (pharmacological treatment)
HJ Treatment or recovery method > Treatment outcome
J Health care, prevention, harm reduction and treatment > Treatment and maintenance > Treatment factors
J Health care, prevention, harm reduction and treatment > Health care programme, service or facility > Hospital
P Demography, epidemiology, and history > Population dynamics > Substance related mortality / death
VA Geographic area > Europe > Sweden
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