Home > Review of industry reports on EU priority tobacco additives part A: main outcomes and conclusions.

Havermans, Anne and Mallock, Nadja and Zervas, Efthimios and Caillé-Garnier, Stéphanie and Mansuy, Thibault and Michel, Cécile and Pennings, Jeroen L A and Schulz, Thomas and Schwarze, Per E and Solimini, Renata and Tassin, Jean-Pol and Vardavas, Constantine I and Merino, Miguel and Pauwels, Charlotte G G M and van Nierop, Lotte E and Lambré, Claude and Bolling, Anette K (2022) Review of industry reports on EU priority tobacco additives part A: main outcomes and conclusions. Tobacco Prevention & Cessation, 8, 27. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255285/.

External website: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC92552...

The European Union Tobacco Products Directive (EU TPD) mandates enhanced reporting obligations for tobacco manufacturers regarding 15 priority additives. Within the Joint Action on Tobacco Control (JATC), a review panel of independent experts was appointed for the scientific evaluation of the additive reports submitted by a consortium of 12 tobacco manufacturers. As required by the TPD, the reports were evaluated based on their comprehensiveness, methodology and conclusions. In addition, we evaluated the chemical, toxicological, addictive, inhalation facilitating and flavoring properties of the priority additives based on the submitted reports, supplemented by the panel's expert knowledge and some independent literature. The industry concluded that none of the additives is associated with concern. Due to significant methodological limitations, we question the scientific validity of these conclusions and conclude that they are not warranted.

Our review demonstrates that many issues regarding toxicity, addictiveness and attractiveness of the additives have not been sufficiently addressed, and therefore concerns remain. For example, menthol facilitates inhalation by activation of the cooling receptor TRPM8. The addition of sorbitol and guar gum leads to a significant increase of aldehydes that may contribute to toxicity and addictiveness. Titanium dioxide particles (aerodynamic diameter <10 µm) are legally classified as carcinogenic when inhaled. For diacetyl no report was provided. Overall, the industry reports were not comprehensive, and the information presented provides an insufficient basis for the regulation of most additives. We, therefore, advise MS to consider alternative approaches such as the precautionary principle.

Item Type
Publication Type
International, Open Access, Review, Article
Drug Type
Tobacco / Nicotine
Intervention Type
Harm reduction
Identification #
European Network for Smoking and Tobacco Prevention

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