Home > Analysis of prenatal exposure to opioid analgesics and scholastic skills in children in fifth grade in Norway.

Trønnes, Johanne Naper and Lupattelli, Angela and Ystrom, Eivind and Nordeng, Hedvig (2022) Analysis of prenatal exposure to opioid analgesics and scholastic skills in children in fifth grade in Norway. JAMA Network Open, 5, (7), e2222425. doi: 10.1001/jamanetworkopen.2022.22425.

External website: https://jamanetwork.com/journals/jamanetworkopen/f...


Question: Is there an association between prenatal exposure to opioid analgesics and fifth-grade scholastic skills?

Findings: In this cohort study of 64 256 children, exposure to opioid analgesics in the first trimester or during two to three 4-week intervals during pregnancy was associated with lower scores in literacy and numeracy tests, compared with only prepregnancy exposure. However, the differences may not be clinically relevant.

Meaning: The findings of this study suggest that there is no association between prenatal exposure to opioid analgesics and fifth-grade scholastic skills.

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