Garrison-Desany, Henri M and Hong, Xiumei and Maher, Brion S and Beaty, Terri H and Wang, Guoying and Pearson, Colleen and Liang, Liming and Wang, Xiaobin and Ladd-Acosta, Christine (2022) Individual and combined association between prenatal polysubstance exposure and childhood risk of attention-deficit/hyperactivity disorder. JAMA Network Open, 5, (3), e221957. 10.1001/jamanetworkopen.2022.1957.
External website: https://jamanetwork.com/journals/jamanetworkopen/f...
Question: Is prenatal exposure to multiple substances, alone or in combination, associated with the risk of attention-deficit/hyperactivity disorder (ADHD) in childhood?
Findings: In this cohort study of 3138 children with and without ADHD, prenatal opioid exposure was significantly associated with the highest childhood risk of ADHD among all substances measured. Interactions between exposure to opioids and cannabis as well as opioids and alcohol were also associated with ADHD risk.
Meaning: This study’s findings suggest that it is important to consider prenatal exposure to multiple substances and the interactions between these substances when counseling women regarding substance use during pregnancy.
[See also, invited commentary: Polysubstance exposure during pregnancy and attention-deficit/hyperactivity disorder in offspring—methodological challenges and opportunities for future research]
B Substances > Substances in general
B Substances > Opioids (opiates)
E Concepts in biomedical areas > Pregnancy
G Health and disease > State of health
G Health and disease > Substance use disorder (addiction) > Multiple substance use (Poly-drug /Poly-substance)
G Health and disease > Disease by cause (Aetiology) > Foetal, infant, newborn diseases (reproductive effects)
G Health and disease > Behavioural and mental health disorder (Psychosis / mood) > Attention deficit hyperactivity disorder (ADHD / ADD)
J Health care, prevention, harm reduction and treatment > Risk and protective factors > Risk factors
T Demographic characteristics > Pregnant woman
T Demographic characteristics > Child of person who uses substances
VA Geographic area > United States
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