Yunusa, Ismaeel and Gagne, Joshua J and Yoshida, Kazuki and Bykov, Katsiaryna (2022) Risk of opioid overdose associated with concomitant use of oxycodone and selective serotonin reuptake inhibitors. JAMA Network Open, 5, (2), e220194. doi: 10.1001/jamanetworkopen.2022.0194.
External website: https://jamanetwork.com/journals/jamanetworkopen/f...
Question: Is concomitant use of oxycodone with selective serotonin reuptake inhibitors (SSRIs) that are potent inhibitors of oxycodone metabolism via the cytochrome-P450 2D6 (CYP2D6) enzyme (fluoxetine and paroxetine) associated with opioid overdose?
Findings: In this cohort study of more than 2 million US adults, use of SSRIs that are potent inhibitors of oxycodone metabolism at the time of oxycodone therapy initiation was associated with a small but significantly higher risk of opioid overdose compared with the use of other, noninhibiting SSRIs.
Meaning: These findings suggest that concomitant use of oxycodone with potent CYP2D6-inhibiting SSRIs may increase
B Substances > Opioids (opiates) > Opioid product
E Concepts in biomedical areas > Medical substance > Prescription drug (medicine / medication)
G Health and disease > Substance use disorder > Drug use disorder > Drug intoxication > Poisoning (overdose)
VA Geographic area > United States
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