Di Castelnuovo, Augusto and Costanzo, Simona and Bonaccio, Marialaura and McElduff, Patrick and Linneberg, Allan and Salomaa, Veikko and Männistö, Satu and Moitry, Marie and Ferrières, Jean and Dallongeville, Jean and Thorand, Barbara and Brenner, Hermann and Ferrario, Marco and Veronesi, Giovanni and Pettenuzzo, Emanuela and Tamosiunas, Abdonas and Njølstad, Inger and Drygas, Wojciech and Nikitin, Yuri and Söderberg, Stefan and Kee, Frank and Grassi, Guido and Westermann, Dirk and Schrage, Benedikt and Dabboura, Salim and Zeller, Tanja and Kuulasmaa, Kari and Blankenberg, Stefan and Donati, Maria Benedetta and de Gaetano, Giovanni and Iacoviello, Licia (2022) Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based study. Addiction, 117, (2), pp. 312-325. doi: 10.1111/add.15593.
External website: https://onlinelibrary.wiley.com/doi/10.1111/add.15...
AIM: To test the association of alcohol consumption with total and cause-specific mortality risk.
DESIGN: Prospective observational multi-centre population-based study. Sixteen cohorts (15 from Europe) in the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Project. A total of 142 960 individuals (mean age 50 ± 13 years, 53.9% men).
MEASUREMENTS: Average alcohol intake by food frequency questionnaire, total and cause-specific mortality.
FINDINGS: In comparison with life-time abstainers, consumption of alcohol less than 10 g/day was associated with an average 11% reduction in the risk of total mortality, while intake > 20 g/day was associated with a 13% increase in the risk of total mortality. Comparable findings were observed for cardiovascular (CV) deaths. With regard to cancer, drinking up to 10 g/day was not associated with either mortality risk reduction or increase, while alcohol intake > 20 g/day was associated with a 22% increased risk of mortality. The association of alcohol with fatal outcomes was similar in men and women, differed somewhat between countries and was more apparent in individuals preferring wine, suggesting that benefits may not be due to ethanol but other ingredients. Mediation analysis showed that high-density lipoprotein cholesterol explained 2.9 and 18.7% of the association between low alcohol intake and total as well as CV mortality, respectively.
CONCLUSIONS: In comparison with life-time abstainers, consuming less than one drink per day (nadir at 5 g/day) was associated with a reduced risk of total, cardiovascular and other causes mortality, except cancer. Intake of more than two drinks per day was associated with an increased risk of total, cardiovascular and especially cancer mortality.
A Substance use and dependence > Prevalence > Substance use behaviour > Alcohol consumption
B Substances > Alcohol
G Health and disease > State of health > Physical health
G Health and disease > Pathologic process > Cancer
G Health and disease > Cardiovascular / heart disease
P Demography, epidemiology, and history > Population dynamics > Substance related mortality / death
VA Geographic area > Europe
Repository Staff Only: item control page