Editorial: Eating disorders (e.g., anorexia nervosa, bulimia nervosa) are associated with high premature mortality and are generally considered to be among the most lethal of all psychiatric disorders (1). Similarly, mortality from substance use disorders has been well documented during the current drug overdose crisis in the United States (2) and in numerous studies showing elevated death rates due to tobacco, alcohol, and other drugs (3–5). Yet, mortality from the combination of eating disorders and substance use disorders has infrequently been studied—a gap now addressed by Mellentin and colleagues, who document that the combined conditions are much more lethal than either disorder alone...