Importance: Cigarette smokers not planning to quit are often overlooked in population studies evaluating the risk-benefit potential of electronic nicotine delivery products (e-cigarettes).

Objective: To evaluate whether e-cigarette use is associated with discontinuing cigarette smoking among smokers who were initially never planning to quit.

Design, Setting, and Participants: This cohort study used US nationally representative data from the longitudinal Population Assessment of Tobacco and Health Study (waves 2-5 conducted between October 2014 and November 2019), with participants evaluated in 3 pairs of interviews. Adult daily cigarette smokers initially not using e-cigarettes and with no plans to ever quit smoking for good (2489 observations from 1600 individuals) were included.

Exposures: e-Cigarette use (ie, daily use, nondaily use, or no use) at follow-up interview among smokers not using e-cigarettes at baseline interview.

Main Outcomes and Measures: The main outcomes were discontinuation of cigarette smoking (ie, no cigarette smoking) and discontinuation of daily cigarette smoking (ie, no daily cigarette smoking) at follow-up interview. Generalized estimating equations were used to evaluate the association between the exposure and each outcome, controlling for demographic characteristics and cigarettes smoked per day at baseline interview; all estimates were weighted.

Results: The weighted population of adult daily cigarette smokers who were not using e-cigarettes and had no plans to ever quit smoking, based on data from 1600 participants, was 56.1% male, 10.1% Hispanic, 10.1% non-Hispanic Black, 75.6% non-Hispanic White, and 4.2% of other non-Hispanic race; 29.3% were aged 55 to 69 years, 8.9% were aged 70 years or older, 36.8% did not graduate from high school, 55.2% had an annual household income of less than $25 000, 37.6% smoked 20 to 29 cigarettes per day, and 12.7% smoked 30 or more cigarettes per day. Overall, 6.2% of the population discontinued cigarette smoking. Discontinuation rates were higher among those who used e-cigarettes daily compared with not at all. Furthermore, 10.7% discontinued daily cigarette smoking, with higher rates of discontinuation observed among those who used e-cigarettes daily compared with not at all. Nondaily e-cigarette use was not associated with cigarette discontinuation or daily cigarette discontinuation.

Conclusions and Relevance: In this cohort study, daily e-cigarette use was associated with greater odds of cigarette discontinuation among smokers who initially had no plans to ever quit smoking. These findings support the consideration of smokers who are not planning to quit when evaluating the risk-benefit potential of e-cigarettes for smoking cessation in the population.