Smith, Colin M and Gilbert, Elizabeth B and Riordan, Paul A and Helmke, Nicole and von Isenburg, Megan and Kincaid, Brian R and Shirey, Kristen G (2021) COVID-19-associated psychosis: a systematic review of case reports. General Hospital Psychiatry, 73, pp. 84-100. doi: 10.1016/j.genhosppsych.2021.10.003.
External website: https://linkinghub.elsevier.com/retrieve/pii/S0163...
OBJECTIVES: To describe the comorbidities, presentations, and outcomes of adults with incident psychosis and a history of COVID-19.
METHODS: We completed a descriptive systematic review of case reports according to PRISMA guidelines, including cases of adult patients with incident psychosis and antecedent or concurrent COVID-19. We extracted patient demographics, comorbidities, clinical course, and outcomes, and assessed cases for quality using a standardized tool.
RESULTS: Of 2396 articles, we included 40 reports from 17 countries, comprising 48 patients. The mean age of patients was 43.9 years and 29 (60%) were males. A total of 7 (15%) had a documented psychiatric history, 6 (13%) had a substance use history and 11 (23%) had a comorbid medical condition. Delusions were the most common (44 [92%]) psychiatric sign and psychosis lasted between 2 and 90 days. A total of 33 (69%) patients required hospitalization to a medical service and 16 (33%) required inpatient psychiatric admission. The majority (26 [54%]) of cases did not assess for delirium and 15 (31%) cases were judged to be of high risk of bias.
CONCLUSIONS: Despite the growing awareness of COVID-19's association with incident psychosis at a population level, cases of COVID-19-associated psychosis often lacked clinically relevant details and delirium was frequently not excluded.
G Health and disease > Disease by cause (Aetiology) > Communicable / infectious disease > Viral disease / infection > Coronavirus (COVID-19)
G Health and disease > Behavioural and mental health disorder (Psychosis / mood)
VA Geographic area > International
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