• For the first time dissolution test method was developed for the determination of in-vitro percentage release of cannabidiol in hemp oil infused products.
• Method utilizes simple and robust reverse phase high performance liquid chromatographic technique with isocratic elution.
• Compared the dissolution profile for the products purchased from Europe and the United States.
• USP apparatus II (Paddles) with 500 mL of dissolution media used.
• Agitation speed of 50 rpm and 500 mL of biorelevant media (simulated gastric and intestinal fluids) used.
• Testing was conducted at 75 and 100 rpm apart from 50 rpm for samples shows poor bioavailability.
• The US products shows better bioavailability as compared to its EU counter parts.