Home > Comparative study of dissolution for cannabidiol in EU and US hemp oil products by HPLC.

Analakkattillam, S and Langsi, V K and Hanrahan, J P and Moore, E (2021) Comparative study of dissolution for cannabidiol in EU and US hemp oil products by HPLC. Journal of Pharmaceutical Sciences, 110, (8), pp. 3091-3098. doi: 10.1016/j.xphs.2021.03.028.

• For the first time dissolution test method was developed for the determination of in-vitro percentage release of cannabidiol in hemp oil infused products.
• Method utilizes simple and robust reverse phase high performance liquid chromatographic technique with isocratic elution.
• Compared the dissolution profile for the products purchased from Europe and the United States.
• USP apparatus II (Paddles) with 500 mL of dissolution media used.
• Agitation speed of 50 rpm and 500 mL of biorelevant media (simulated gastric and intestinal fluids) used.
• Testing was conducted at 75 and 100 rpm apart from 50 rpm for samples shows poor bioavailability.
• The US products shows better bioavailability as compared to its EU counter parts.


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