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Home > Clinical, electrophysiological and radiological features of nitrous oxide-induced neurological disorders.

Bao, Lei and Li, Qing and Li, Qingjie and Chen, Hao and Zhang, Ruixue and Shi, Hongjuan and Cui, Guiyun (2020) Clinical, electrophysiological and radiological features of nitrous oxide-induced neurological disorders. Neuropsychiatric Disease and Treatment , 16 , pp. 977-984. doi: 10.2147/NDT.S236939.

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC71672...

Purpose: We summarized the clinical manifestations, laboratory and electrodiagnostic characteristics and magnetic resonance imaging (MRI) findings of nitrous oxide (NO) abuse-induced neurological disorders.

Patients and Methods: We retrospectively reviewed 33 patients with NO abuse-induced neurological disorders and reported their demographic data, clinical manifestations, laboratory examinations, nerve conduction studies, together with spinal and brain MRI.

Results: The most frequent clinical manifestations included numbness and weakness in the extremities and unspecified gait disturbance. Low serum vitamin B levels were found in 9 patients, and high homocysteine levels were noted in 27 patients. Nerve conduction studies showed a sensory-motor neuropathy. Sixteen patients showed bilateral high-intensity T2 signal within the posterior column on spinal MRI, and four patients showed cerebral white matter lesions on brain MRI.

Conclusion: NO abuse has become a significant public health problem because of the severe neurological disorders related to chronic abuse. Clinical physicians should be aware of the toxic effects of NO.


Item Type
Article
Publication Type
International, Open Access, Article
Drug Type
Inhalents and solvents
Intervention Type
General / Comprehensive, Harm reduction
Date
April 2020
Identification #
doi: 10.2147/NDT.S236939
Pages
977-84
Page Range
pp. 977-984
Volume
16
EndNote

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