Home > Comparative effectiveness of different treatment pathways for opioid use disorder.

Wakeman, Sarah and Larochelle, Marc R and Ameli, Omid and Chaisson, Christine and McPheeters, Jeffrey Thomas and Crown, William H and Azocar, Francisca and Sanghavi, Darshak M [JAMA] . (2020) Comparative effectiveness of different treatment pathways for opioid use disorder. JAMA Network Open, 3 (2: e1920622) 10.1001/jamanetworkopen.2019.20622

URL: https://jamanetwork.com/journals/jamanetworkopen/f...

Question: What is the real-world effectiveness of different treatment pathways for opioid use disorder?

Findings: In this comparative effectiveness research study of 40 885 adults with opioid use disorder that compared 6 different treatment pathways, only treatment with buprenorphine or methadone was associated with reduced risk of overdose and serious opioid-related acute care use compared with no treatment during 3 and 12 months of follow-up.

Meaning: Methadone and buprenorphine were associated with reduced overdose and opioid-related morbidity compared with opioid antagonist therapy, inpatient treatment, or intensive outpatient behavioral interventions and may be used as first-line treatments for opioid use disorder.


Item Type:Evidence resource
Drug Type:Opioid
Intervention Type:AOD disorder, AOD disorder drug therapy, AOD disorder treatment method, Psychosocial treatment method
Source:JAMA
Date:February 2020
Volume:3
Number:2: e1920622
EndNote:View
Subjects:B Substances > Opioids (opiates)
B Substances > Opioids (opiates) > Opioid product > Buprenorphine / Suboxone
G Health and disease > Substance use disorder > Drug use > Drug intoxication > Poisoning (overdose)
HJ Treatment method > Substance disorder treatment method
HJ Treatment method > Substance disorder treatment method > Substance replacement method (substitution) > Methadone maintenance
HJ Treatment method > Treatment outcome
J Health care, prevention and rehabilitation > Treatment and maintenance > Treatment factors
VA Geographic area > United States

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