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Home > Comparative effectiveness of different treatment pathways for opioid use disorder.

Wakeman, Sarah and Larochelle, Marc R and Ameli, Omid and Chaisson, Christine and McPheeters, Jeffrey Thomas and Crown, William H and Azocar, Francisca and Sanghavi, Darshak M (2020) Comparative effectiveness of different treatment pathways for opioid use disorder. JAMA Network Open , 3 , (2: e1920622) . 10.1001/jamanetworkopen.2019.20622.

URL: https://jamanetwork.com/journals/jamanetworkopen/f...

Question: What is the real-world effectiveness of different treatment pathways for opioid use disorder?

Findings: In this comparative effectiveness research study of 40 885 adults with opioid use disorder that compared 6 different treatment pathways, only treatment with buprenorphine or methadone was associated with reduced risk of overdose and serious opioid-related acute care use compared with no treatment during 3 and 12 months of follow-up.

Meaning: Methadone and buprenorphine were associated with reduced overdose and opioid-related morbidity compared with opioid antagonist therapy, inpatient treatment, or intensive outpatient behavioral interventions and may be used as first-line treatments for opioid use disorder.


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