Home > Adolescent binge drinking disrupts normal trajectories of brain functional organization and personality maturation.

Ruan, Hongtao and Zhou, Yunyi and Luo, Qiang and Robert, Gabriel H and Desrivières, Sylvane and Quinlan, Erin Burke and Liu, ZhaoWen and Banaschewski, Tobias and Bokde, Arun L W and Bromberg, Uli and Büchel, Christian and Flor, Herta and Frouin, Vincent and Garavan, Hugh and Gowland, Penny and Heinz, Andreas and Ittermann, Bernd and Martinot, Jean-Luc and Martinot, Marie-Laure Paillère and Nees, Frauke and Orfanos, Dimitri Papadopoulos and Poustka, Luise and Hohmann, Sarah and Fröhner, Juliane H and Smolka, Michael N and Walter, Henrik and Whelan, Robert and Li, Fei and Schumann, Gunter and Feng, Jianfeng . (2019) Adolescent binge drinking disrupts normal trajectories of brain functional organization and personality maturation. NeuroImage. Clinical, 22 (101804) doi: 10.1016/j.nicl.2019.101804

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64511...

Adolescent binge drinking has been associated with higher risks for the development of many health problems throughout the lifespan. Adolescents undergo multiple changes that involve the co-development processes of brain, personality and behavior; therefore, certain behavior, such as alcohol consumption, can have disruptive effects on both brain development and personality maturation. However, these effects remain unclear due to the scarcity of longitudinal studies. In the current study, we used multivariate approaches to explore discriminative features in brain functional architecture, personality traits, and genetic variants in 19-year-old individuals (n = 212).

Taking advantage of a longitudinal design, we selected features that were more drastically altered in drinkers with an earlier onset of binge drinking. With the selected features, we trained a hierarchical model of support vector machines using a training sample (n = 139). Using an independent sample (n = 73), we tested the model and achieved a classification accuracy of 71.2%. We demonstrated longitudinally that after the onset of binge drinking the developmental trajectory of improvement in impulsivity slowed down. This study identified the disrupting effects of adolescent binge drinking on the developmental trajectories of both brain and personality.


Item Type:Evidence resource
Drug Type:Alcohol
Intervention Type:AOD disorder, AOD disorder harm reduction
Date:2019
Page Range:p. 101804
Volume:22
Number:101804
EndNote:View
Subjects:A Substance use, abuse, and dependence > Prevalence > Substance use behaviour > Alcohol consumption > Binge / risky drinking
A Substance use, abuse, and dependence > Prevalence > Substance use behaviour > Alcohol consumption
B Substances > Alcohol
E Concepts in biomedical areas > General life processes (physiology)
F Concepts in psychology > Emotion (anxiety, emotional pain)
F Concepts in psychology > Specific attitude and behaviour > choice-making behaviour
F Concepts in psychology > Specific attitude and behaviour > risk-taking behaviour
J Health care, prevention and rehabilitation > Risk and protective factors > Risk factors

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