Home > A single alcohol binge impacts on neutrophil function without changes in gut barrier function and gut microbiome composition in healthy volunteers.

Stadlbauer, Vanessa and Horvath, Angela and Komarova, Irina and Schmerboeck, Bianca and Feldbacher, Nicole and Wurm, Sonja and Klymiuk, Ingeborg and Durdevic, Marija and Rainer, Florian and Blesl, Andreas and Stryeck, Sarah and Madl, Tobias and Stiegler, Philipp and Leber, Bettina [PLOS One] . (2019) A single alcohol binge impacts on neutrophil function without changes in gut barrier function and gut microbiome composition in healthy volunteers. Public Library of Science. PLoS ONE, 14 (2)

URL: https://journals.plos.org/plosone/article?id=10.13...

Alcohol binge drinking is a dangerous drinking habit, associated with neurological problems and inflammation. The impact of a single alcohol binge on innate immunity, gut barrier and gut microbiome was studied. In this cohort study 15 healthy volunteers received 2 ml vodka 40% v/v ethanol/kg body weight. Neutrophil function was studied by flow cytometry; markers of gut permeability and inflammation (lactulose/mannitol/sucrose test, zonulin, calprotectin, diamino-oxidase) were studied with NMR spectroscopy and enzyme-linked immunosorbent assay in urine, stool and serum respectively. Bacterial products in serum were quantified using different reporter cell lines. Gut microbiome composition was studied by 16S rDNA sequencing and bioinformatics analysis. After a single alcohol binge, neutrophils were transiently primed and the response to E.coli stimulation with reactive oxygen species (ROS) production was transiently increased, on the other hand the percentage of neutrophils that did not perform phagocytosis increased. No changes in gut permeability, inflammatory biomarker, bacterial translocation and microbiome composition could be detected up to 4 hours after a single alcohol binge or on the next day.

A single alcohol binge in young, healthy volunteers transiently impacts on neutrophil function. Although the exact biological consequence of this finding is not clear yet, we believe that this strengthens the importance to avoid any alcohol binge drinking, even in young, otherwise healthy persons.


Item Type:Evidence resource
Drug Type:Alcohol
Intervention Type:AOD disorder, AOD disorder harm reduction
Source:PLOS One
Date:February 2019
Page Range:e0211703
Publisher:Public Library of Science
Volume:14
Number:2
EndNote:View
Subjects:A Substance use, abuse, and dependence > Prevalence > Substance use behaviour > Alcohol consumption > Binge / risky drinking
A Substance use, abuse, and dependence > Prevalence > Substance use behaviour > Alcohol consumption
B Substances > Alcohol
G Health and disease > State of health > Physical health
G Health and disease > Digestive system disorder

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