Home > What are the benefits and harms of naloxone for opiate‐exposed newborn infants?

Davis, Mark [The Cochrane Library] . (2018) What are the benefits and harms of naloxone for opiate‐exposed newborn infants? London: Wiley. Cochrane Clinical Answers

URL: https://www.cochranelibrary.com/cca/doi/10.1002/cc...

No randomized controlled trial evidence suggests that giving naloxone to all babies who have been exposed to maternal opioids (for analgesia in labor) improves clinically meaningful outcomes over placebo or no treatment.

Some of the nine trials, enrolling 316 newborn infants in total, did report improvement in measures of respiratory function (expired carbon dioxide and alveolar ventilation); however, these outcomes are of little clinical relevance.

Serious theoretical risk of harm to infants at risk of neonatal abstinence syndrome secondary to long‐term in utero exposure to opioids (either illicit or for chronic pain) remains. Naloxone given to such infants may cause acute withdrawal and seizures.


Item Type:Evidence resource
Drug Type:Opioid
Intervention Type:AOD disorder, AOD disorder drug therapy, AOD disorder harm reduction
Source:The Cochrane Library
Date:December 2018
Publisher:Wiley
Place of Publication:London
EndNote:View
Subjects:B Substances > Opioids (opiates)
B Substances > Opioids (opiates) > Opioid product > Naloxone
HJ Treatment method > Substance disorder treatment method > Substance disorder drug therapy
N Communication, information and education > Recommendations or guidelines > Practice / clinical guidelines
T Demographic characteristics > Child of drugs and alcohol user

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