Home > Clinical question: What are the effects of opioid substitution therapy and needle syringe programs for preventing hepatitis C transmission in people who inject drugs?

Burch, Jane and Tort, Sera [The Cochrane Library] . (2018) Clinical question: What are the effects of opioid substitution therapy and needle syringe programs for preventing hepatitis C transmission in people who inject drugs? London: Wiley. Cochrane Clinical Answers

URL: https://www.cochranelibrary.com/cca/doi/10.1002/cc...

Use of opioid substitution therapy (OST), with or without a needle syringe program (NSP), appears to reduce the number of people who inject drugs and develop hepatitis C compared with no OST use (no absolute numbers per 1000 were available; on average, reduction was 50% with OST vs no OST, and 55% with OST plus NSP vs no OST plus low or no NSP). NSP alone shows no clear differences between groups overall (low vs no NSP coverage, or high vs low/no NSP), although subgroup analyses based on region suggest that fewer people in Europe may develop hepatitis C with high NSP than with low/no NSP coverage (on average, reduction was 76%). When assessed, the quality of evidence was very low to low. No firm conclusions can be drawn.


Item Type:Evidence resource
Publication Type:Guideline
Drug Type:Opioid
Intervention Type:AOD disorder, AOD disorder drug therapy, AOD disorder treatment method, AOD disorder harm reduction
Source:The Cochrane Library
Date:4 April 2018
Publisher:Wiley
Place of Publication:London
EndNote:View
Subjects:B Substances > Opioids (opiates)
B Substances > Opioids (opiates) > Opioid product
G Health and disease > Etiology > Disease transmission factor > Needle sharing
G Health and disease > Disorder by cause > Communicable disease > Hepatitis C
HJ Treatment method > Substance disorder treatment method > Substance replacement method (substitution)
J Health care, prevention and rehabilitation > Substance use prevention > Substance use harm reduction
J Health care, prevention and rehabilitation > Health related prevention > Health information and education > Communicable disease control
J Health care, prevention and rehabilitation > Health related prevention > Health information and education > Communicable disease control > Needle distribution and exchange
J Health care, prevention and rehabilitation > Patient care management
N Communication, information and education > Recommendations or guidelines > Practice / clinical guidelines
T Demographic characteristics > Intravenous / injecting drug user

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