Home > Clinical question: What are the benefits and harms of buprenorphine maintenance versus placebo or methadone maintenance in people with opioid dependence?

Magalhães, Pedro V [The Cochrane Library] . (2014) Clinical question: What are the benefits and harms of buprenorphine maintenance versus placebo or methadone maintenance in people with opioid dependence? London: Wiley. Cochrane Clinical Answers

URL: https://www.cochranelibrary.com/cca/doi/10.1002/cc...

Buprenorphine, a partial opioid agonist, has pharmacological features, including safety at overdose and ease of use, which make it an interesting alternative to methadone for those with heroin use disorders. However, buprenorphine maintenance, although effective compared with placebo, was inferior to methadone in retaining people in treatment. There were no clear differences between the drugs on the other primary outcomes (drug use, safety, criminal activity).


Item Type:Evidence resource
Publication Type:Guideline
Drug Type:Opioid
Intervention Type:AOD disorder, AOD disorder drug therapy, AOD disorder treatment method
Source:The Cochrane Library
Date:25 November 2014
Publisher:Wiley
Place of Publication:London
EndNote:View
Subjects:A Substance use, abuse, and dependence > Effects and consequences
B Substances > Opioids (opiates)
B Substances > Opioids (opiates) > Opioid product
B Substances > Opioids (opiates) > Opioid product > Buprenorphine / Suboxone
B Substances > Opioids (opiates) > Opioid product > Methadone
HJ Treatment method > Substance disorder treatment method
HJ Treatment method > Substance disorder treatment method > Substance disorder drug therapy
HJ Treatment method > Treatment outcome
J Health care, prevention and rehabilitation > Patient care management
N Communication, information and education > Recommendations or guidelines > Practice / clinical guidelines

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