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Home > Clinical question: How does buprenorphine compare with methadone or adrenergic agonists in people undergoing opioid withdrawal?

Burch, Jane and Magalhães, Pedro V [The Cochrane Library] . (2017) Clinical question: How does buprenorphine compare with methadone or adrenergic agonists in people undergoing opioid withdrawal? London: Wiley. Cochrane Clinical Answers

URL: https://www.cochranelibrary.com/cca/doi/10.1002/cc...

Buprenorphine seems to provide benefits over adrenergic agonists in terms of reduction of withdrawal symptoms and retention in treatment, with a similar adverse event profile. When compared with methadone, buprenorphine seems as effective, but analyses included few people and none of the evidence was high quality.


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